Melatonin and Weed for Sleep: Instructive Insights

Melatonin and Weed for Sleep - Which is More Effective?

Melatonin and Weed: A Connection

Melatonin is a hormone that helps alert the brain when it needs to sleep or wake up. It helps us regulate our body temperature by acting on receptors in the hypothalamus, which regulates blood flow through the skin and blood pressure through the autonomic nervous system.

The human body produces Melatonin during the night. This process is responsible for our body’s circadian rhythm, which regulates our sleep-wake cycle. 

“Until I started experiencing insomnia, I had no idea it was possible to be this furious with each of my pillows individually.”

While Marijuana is mainly known as a recreational drug that provides people with the ability to relieve stress and sleep disorders, it also has many therapeutic uses, including treating depression symptoms and insomnia associated with narcolepsy. 


How Do Sleep Patterns Change as You Age?

Melatonin and Weed

Sleep disorders are a significant source of morbidity and mortality in elderly populations. They can be associated with illnesses like Alzheimer’s disease, dementia, or sleep apnea syndrome (SAS), characterized by interrupted breathing during sleep.

Sleep is one of the most fundamental functions of the human body. It affects over 100,000 bodily systems in the human body and can affect everything from weight to mood. Sleep patterns can change as people age, and there is a growing body of research on this topic.

The human body is constantly in a state of change. When we get less sleep, our bodies do not adapt to the new situation. When we sleep less, our body has to work hard to balance out the amount of sleep. Lack of sleep leads to lower performance and decreased quality of life for us as an individual.

As we get older, it is not uncommon for us to notice that our bodies are changing and that there is a decrease in the number of hours we sleep, leading to increased stress and depression in individuals. It can also lead to health issues such as obesity and diabetes prevalent among older people today.


A Balanced Approach to Sleep

The way we sleep has a massive impact on our productivity. It affects our mood, concentration, and overall state of mind.

A balanced approach to sleep will lead to more happy and productive days.

Sleep is a critical need but not a luxury. So, as humans, we need to balance our sleep time with other things in our life. We also need to make sure that we don’t overdo it.

There are some sleep aids available for people who have insomnia or other types of sleep disorders. However, using these aids will not solve the problem because they only treat the symptom and do not address the root cause of insomnia.

An easy solution is a simple bedtime ritual – read a book or listen to music before going to bed and do some meditation or relaxation exercises before getting into bed.


How Does Melatonin Work?

Melatonin and Weed_How Does Melatonin Work?

Melatonin secretion also plays a role in mood regulation (e.g., serotonin levels, neurotransmitter levels). Melatonin regulates sleep/wakefulness cycles through simple mechanisms involving receptors on the hypothalamus and pituitary gland cells. 

Various pharmaceuticals (e.g., antidepressants) work by mimicking or inhibiting this hormone production process and decreasing stress levels.


Is Melatonin a Hormone?

Melatonin is a natural hormone secreted by the brain’s pineal gland, which regulates sleep and wakefulness. Its primary function is to regulate circadian rhythm, the so-called biological clock mechanism that controls when and how long you stay awake in real-time.


Is Melatonin Safe for kids?

Several studies have shown that adults and children can safely take up to 800mg of Melatonin daily without any adverse effects. When we consume supplements over a long period (for example, for several weeks), they may cause nausea or insomnia (and it may not be safe if you are pregnant or have other medical conditions).


How Does Weed Affect Melatonin?

Melatonin and Weed for Sleep - How Does Weed Affect Melatonin?

Cannabinoids affect Melatonin production by suppressing and inhibiting activity via interaction with CB1 receptors in the brain. Research indicates that Cannabis may affect Melatonin levels by increasing levels of CB1 receptors in the brain and by increasing GABA concentrations in the brain via CB1 receptors.


Cannabis or Melatonin: Is One Better For Sleep?

Research suggests that Cannabis may help with sleep problems. Cannabis can stimulate a person to fall asleep quicker than usual. It also allows people to stay asleep longer and is effective against insomnia.

Other research shows that Melatonin is a better sleep aid than Cannabis. Melatonin helps people feel more awake during the day, even when they are sleepy at night or have trouble falling asleep in the evening. Some studies suggest Melatonin also helps people relax better during sleep – especially those who suffer from insomnia or nightmares – but this does not mean one is better than another for sleep benefits:


Melatonin and Weed (Marijuana) for Sleep: Can You Take Them Together?

Melatonin is responsible for regulating circadian rhythm and thus for maintaining our sleeping and waking abilities. Increasing the production of this hormone may help people get more restful sleep; however, its adverse effects can also be linked to its excessive use (as in recreational drug use).

The famous experiment performed by Dr. Michael Posner (2006) found that having the same amount of THC in the bloodstream did not affect Melatonin levels – neither from Marijuana nor from other substances.


Melatonin, THC, or CBD- Which is the Best Sleep Aid?

Melatonin and THC are two sleep aid drugs commonly prescribed for insomnia. These sleep aids are used for treating insomnia as they effectively increase the amount of time spent sleeping and lower the risk of various types of cancer. However, it is essential to note that these sleep aids have different side effects.

CBD or Cannabidiol is a cannabinoid drug with a non-signaling psychoactive effect, with no side effects. The drug works just like Melatonin which increases the body’s production of endorphins (which help the body calm down) and thus helps in reducing symptoms of depression and anxiety. 

CBD does not have any harmful side effects on the human body because CBD does not interact with any chemical receptors in our brain! It is safe to use

According to the World Health Organization (WHO), Melatonin is a sleep aid that can help people fall asleep, wake up refreshed, and stay asleep. It is also known for protecting against circadian rhythm disruption and protecting against cancer growth.


Can you overdose on Melatonin?

Melatonin and Weed_can you overdose

Melatonin is a powerful natural hormone, and overdosing is unlikely and difficult to detect. However, some users have stated that taking too much Melatonin can cause insomnia. To avoid this, pay careful attention to recommended dosages and, as always, “Start low and go slow.”


Melatonin Hypnosis Interactions

Melatonin hypnotizes the brain’s “sleep” process. It causes the brain to produce more Melatonin hormones, which induces sleepiness. Some studies indicate that hypnotized people also have a higher chance of getting into a deep sleep and falling off into unconsciousness. Studies suggest that hypnosis may help people with poor sleep habits, including insomnia.


Melatonin Linctus Interactions

Melatonin interacts with several essential signaling and non-signaling molecules, and this interaction structure is what determines its biological functions. 

Details on drug Interactions between codeine and Melatonin are available here.


Melatonin Waking Effects

We have plenty of information on Melatonin. We know it has several practical uses, like regulating body temperature and increasing alertness during sleep. The rise in Melatonin levels during waking hours also plays a role in mood regulation and even helps us feel more awake than usual. Some studies show that older people are more sensitive to Melatonin’s effects on their sleep schedules and wakefulness levels than younger people.

The elderly use Melatonin to help them fall asleep faster. It is thought that Melatonin can help the body adjust to light exposure changes and make it easier for seniors to wake up when daylight hours get longer.


Melatonin and Pregnancy

Melatonin has essential effects on pregnancy and birth. It influences the sleep phase, affecting the risk of low birth weight and preterm delivery.

Recent studies have found that pregnancy may reduce Melatonin levels. So it is a good idea to have Melatonin supplements on hand if your hormones are not as stable as they usually are.

Melatonin’s interaction with RXR and PXR is vital for its regulation in pregnancy. Melatonin helps to regulate blood sugar levels, fat storage, energy production, appetite control, and sleep patterns during pregnancy.


Best Weed Strains for Sleep

Melatonin-and-Weed-for-Sleep Best Weed Strains for Sleep


Grandaddy Purple

Grandaddy Purple is a cross between Big Bud and Purple Urkle.

Grandaddy Purple is one of the best Weed strains to use if you have trouble sleeping because it has a calming effect that will help you relax and drift off into dreamland. You can also use it for treating nausea, chronic pain, anxiety, and depression.

The name “Granddaddy Purple” comes from the color of this strain’s vibrant lavender buds with hints of purple.

  • Has a sweet, earthy grape scent with a hint of lavender.

  • Great for staying in one place and relaxing for hours on end.

  • Timeless classic that will never go out of style.

  • A popular Indica strain with a sweet berry taste that provides strong body highs.

  • Granddaddy Purple is good for those seeking good body highs without being too mentally affected.

  • Known to be the most well-known ‘purple’ Cannabisstrain in the US, it has won many CannabisCups.

More on Grandaddy Purple


Northern Lights

The Northern Lights strain induces sleep without causing too much energy crash. The Northern Lights strain has THC levels of 18-21%. It is not only effective for sleep, but it also relieves depression and anxiety.

Northern Lights is known as one of the best strains for getting high and quickly becoming sleepy. It’s perfect for those who want to fall asleep before their brain starts to drift into dreamland.

  • Northern Lights is an award-winning Indica dominant strain.

  • With a touch of Sativa, this strain is perfect for those with chronic pain and insomnia.

  • The THC level is moderate, making this a great daytime medication to alleviate anxiety and muscle spasms.

  • Northern Lights is a well-balanced Cannabis plant with a rich history, making it the perfect strain for any experience level.

  • Created in the 1980s, Northern Lights won many awards and is still celebrated today as one of the most reliable, potent Indica strains on the medical and recreational markets.

  • This strain has a high THC content ranging from 12% to 18%, making it an excellent option for any experience level.


More on Northern Lights 


Afghan Kush

Afghan Kush is famous for its strong sedative effects. It is perfect for people who have insomnia or have trouble sleeping.

This strain has a heavy body high and sedative effects, making it perfect for winding down at bedtime. This strain is well known for its powerful pain relief properties, which allow you to restful sleep and wake up in the morning feeling refreshed.

The plant grows tall with large leaves that are dark-green in color. The flowers are typically purple with red hairs. Afghan Kush typically has an earthy smell and taste.

  • Afghani Kush is the most recognizable Indica landrace strain.

  • So well known, it’s become synonymous with pure Indica strains.

  • Perfect for chilling out and enjoying life before bedtime or after a long day of work.

  • For those who want to wind down and unwind, this strain is for you. The heavy Indica content will put you in a pleasant body buzz and mind relaxation state.

  • Slow-burning so you can enjoy every flavor without feeling too high or too sedated.


More on Afghan Kush

God’s Gift

God’s Gift Strain is a hybrid Cannabis strain known for its potency. 

The Sativa dominant strain provides relaxation. It can help with anxiety, depression, pain relief, and inflammation.

It has a THC content of 20-25%. It has a piney smell and provides a relaxing sensation. It has been known to induce appetite and reduce stress.

  • It is beloved by its loyal fans for its sweet taste, pleasurable effects, and ability to ease stress, depression, fatigue, and chronic pain symptoms.

  • Produces an uplifting sensation that’s perfect for some quality time by yourself or with loved ones.

  • The Godfather of some of the best strains on the market today.

  • A potent blend of OG Kush and XJ-13, the genetics of this strain make it an ideal choice for consumers who are new to medical or recreational Cannabis.

  • Incredibly frosty with an earthy aroma, this high THC selection is the perfect pick for people who want a heady effect combined with a strong sense of focus and mental clarity.


More on God’s Gift

Tahoe OG Kush

Tahoe OG Kush is a Cannabisstrain that helps people who have insomnia. It helps create a relaxing sensation in the body, which promotes sleep.

This strain has an earthy flavor, with hints of pine and citrus. Tahoe OG Kush induces a heavy body high that can put off some users, but it can also relieve pain and other physical ailments like insomnia.

  • A potent Indica-leaning strain with a THC level between 20% and 23% on average.

  • Tahoe OG relieves pain, anxiety, insomnia, and nausea, known for its soothing effects.

  • This Indica provides a deep body high lasting around 2 to 3 hours.

  • Roots in the California hippie movement when Weed was still illegal.

  • Mostly Indica, but some strains lean more to the Sativa side.

  • It started in Lake Tahoe and now grows all over California and beyond.


More on Tahoe Kush


Harlequin is an indica dominant hybrid which means its effects are mainly soothing and relaxing. This makes it perfect for nighttime use and medical patients who need to sleep or manage chronic pain.

The strain has a THC content between 12-18%, translating to medium strength potency.

  • It has a significant uplifting effect with the ability to relax without sedation.

  • Clear-headed in nature, with an expressive CBD content that can help with anxiety.

  • It comes from Colombian Gold, Nepali indica, and Afghani hash plants.

More on Harlequin


Can I Mix CBD Oil with Melatonin?

Yes, you can mix them. CBD oil is a type of ‘non-psychoactive’ cannabinoid drug. The active part of this cannabinoid drug helps get rid of pain, anxiety and depression, and similar problems. It only has a minor effect on sleep and appetite. 

On the other hand, Melatonin belongs to a group of chemicals that can help regulate sleep patterns and appetite when needed by sleeping people. These chemicals are produced in our bodies at night when we sleep.

It is important to be aware of Cannabis and prescription drug interactions. Our article “Can you Smoke Weed on Antibiotics?” will be very helpful.


Can you mix Melatonin and alcohol?

Mixing alcohol and Melatonin is not a good idea. It may cause a hangover, so if you plan to have Melatonin, it’s better to avoid alcohol before bed.

A recent study by the University of California, Los Angeles found that Melatonin, a hormone produced in the pineal gland in the brain that helps us sleep, effectively combats alcohol’s impact on our circadian rhythms.


What are other options for getting better sleep?

Sleep problems can have severe consequences like bad moods, fatigue, tiredness, sadness, irritability, or even panic attacks. Our modern society has more information and easier access to information than ever before – from social media to search engines – so we must get enough sleep, not only for our mental health but also for our physical health.


Meditation or yoga

Meditation helps in enhancing the immune system and reduces anxiety levels. It boosts Melatonin production, which helps promote deep relaxation and restful sleep.


Sound therapy

This therapy uses sounds, either through headphones or just using the activities of daily living, as an aid in improving sleep quality (e.g., taking a shower at night). The goal is to remove unwanted noise from one’s environment by using less light and allowing more time for relaxing to happen naturally without being disturbed by other sounds or images present.


Get more fresh air during the day.

This is important if you sleep poorly due to smoke or other environmental factors. However, this does not address other causes like chronic stress or being in bed too late at night.


Sleep on your side

Deep breathing puts you in a comfortable position to sleep. You will feel more relaxed since your head will be in the right place when you go to sleep. Decreases anxiety.


Don’t watch TV

Watching TV for hours can cause insomnia and make it harder to fall asleep at night. Go for reading, listening to music, or working on something else that keeps you busy. Also, try a few hours of relaxing time with family and friends who come over for dinner or another social event before having a good night’s rest.


Get more light

Bright light stimulates our brains’ production of serotonin (a neurochemical that helps us feel relaxed). This neurochemical is vital for the production of Melatonin during the nighttime hours. 


How to Reset Your Internal Sleep Clock

The internal sleep clock is set on the circadian rhythm of our body. A person’s sleep/wake cycle changes from one day to the next. If a person is not in sync with their own sleep/wake cycle and if this happens frequently, they may suffer from many health issues such as depression, fatigue, and insomnia.

Some people use an app that helps you reset your body clock to get back on track in your sleep habits and live a more balanced life. Take a look here to see how apps like ‘RISE’ make it easy to improve your sleep.


Scientific Papers: Melatonin and Weed for Sleep – Instructive Insights

Cannabinoids, Endocannabinoids and Sleep

Effects of Cannabis on Neurocognitive Functioning: Recent Advances, Neurodevelopmental Influences, and Sex Differences

Hypnosis Intervention Effects on Sleep Outcomes: A Systematic Review

Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases

Melatonin | UCLA Health Library, Los Angeles, CA

Melatonin in Aging and Disease —Multiple Consequences of Reduced Secretion, Options, and Limits of Treatment

Pediatric sleep disturbances and treatment with Melatonin

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